Market Overview

Global Protein Engineering Market size was valued at USD 3.84 Billion in 2023 and is poised to grow from USD 4.49 Billion in 2024 to USD 15.70 Billion by 2032, growing at a CAGR of 16.9% in the forecast period (2024-2032).

The global protein engineering industry is a rapidly evolving and rapidly developing field driven by the new biotechnology, genetic engineering, and computer biology. Protein engineering is with designing, developing, and creating proteins to work optimally in specific applications across various industries. The new science utilizes approaches such as directed evolution, rational design, and de novo synthesis to design proteins that are more stable, active, specific, and therapeutic.

Market expansion is fuelled by increasing demand for biopharmaceuticals, enzymes, and novel protein-based therapeutics to address unmet medical needs, particularly in the treatment of chronic and genetic diseases. Biologics, including monoclonal antibodies, therapeutic enzymes, and vaccines, have revolutionized the pharmaceutical industry, fuelling research and development in protein engineering. Application of protein-based solutions in industrial processes, including in detergents, food processing, and biofuels, has also fuelled market expansion.

Technological breakthroughs in computational tools, machine learning, and artificial intelligence have shortened protein design times to make them cheaper and more accurate. Complementarity between CRISPR and other gene-editing technologies has facilitated correct editing, and the ability to engineer proteins with tailored functions for specific applications. Interaction among academia, industry, and governments is fuelling innovation, providing market players with sufficient chances to diversify their portfolios and provide novel solutions.

Regulatory and ethical concerns are the all-pervading drivers of the market forces. Outstanding balance of safety and innovation is critical, especially when creating proteins for therapy. Stringent preclinical and clinical trials verify engineered proteins to be safe and effective, thus establishing stakeholder and end-user confidence.

The global market for protein engineering is likely to expand in the long term with increased cooperation among key players, regular research activity, and increased application in the pharmaceutical, diagnostic, agricultural, and industrial process industries. The focus on sustainability and the production of environmentally friendly products further brings out the transformative character of protein engineering to address global challenges. With the advent of new technologies in the future, the industry will witness unmatched development, culminating in precision-designed protein-powered future.

Market Drivers

Increasing Adoption of Protein-Based Industrial Applications

• International demand for protein engineering is primarily propelled by the augmented application of protein-based industrial processes. The flexibility and eco-friendly nature of proteins have resulted in their augmented application across industries such as food processing, agriculture, biofuel, detergents, and cosmetics. Proteins are used as functional food ingredients to improve nutritional value, taste, and texture. Plant proteins are also engineered as alternative products to animal-based products. Genetically modified proteins are also being utilized agriculturally to develop new biofertilizers, enhance crop protection, and enhance yield.
• Proteins are genetically modified to optimize biomass conversion to fuel in the biofuels industry, offering cleaner sources of energy. The cleaning market uses enzymes produced from genetically modified proteins to clean better and break down stains, offering eco-friendly alternatives to chemicals for dissolving stains. Minimizing the environmental impact of conventional processes, such business applications are an effective and cost-efficient solution. Since protein-based products are increasingly being used by industries for its unique features, i.e., low toxicity, biodegradability, and specificity, protein engineering is expanding and developing.

Key Findings:

• Monod Bio launched a new, first ever, fully De Novo protein product in July 2024. The world's first commercially available de novo luciferases, Luciferase LuxSit™ Pro, are designed to revolutionize clinical and life sciences research in the years to come through the use of artificial intelligence to create next-generation protein engineering products.
• A novel company employing artificial intelligence to revolutionize protein engineering raised USD 24 million in a funding round in November 2023. The funding round was arranged by Cradle, a novel company with Swiss and Dutch heritage, to develop a novel generative AI model for designing protein-based drugs and chemicals.

Growing Investment in Biotechnology and Life Sciences Research

• Increasing expenditure on biotechnology and life sciences research is a major driver behind the growth of the global protein engineering market. With the ever-growing demand for new healthcare products, including biopharmaceuticals, targeted therapies, and personalized medicine, governments, academia, and private institutions are escalating their investments in biotechnology and life sciences research. These investments are critical to developing next-generation technologies such as gene editing, synthetic biology, and next-generation protein engineering methods. By investing in research around protein structure-function relationships, drug discovery, and biologics manufacturing, investors are speeding up the pace of scientific advances that lead to new disease treatments for cancer, genetic diseases, and autoimmune diseases.
• The increase in funding facilitates the formation of biotechnology startups and partnerships between pharmaceutical firms and research institutions, making the market more dynamic and competitive. The funding allows researchers to investigate new protein engineering techniques, maximize protein production, and improve therapeutic uses. Consequently, increasing investments are not only driving protein engineering advancements but also setting the biotechnology industry to tackle global health issues, in turn propelling market growth and opening new prospects in the field of protein engineering.

Market Opportunities

Increasing Collaboration Between Academia and Industry

• Promotion of collaboration between industry and academia is one of the key market growth drivers in the area of protein engineering. Academic institutions need to play a part in being ahead at the margins of basic research and innovation and developing new technology and ideas. The industry professionals provide the required infrastructure, capital, and business acumen in converting these advances into beneficial solutions. Collaboration enables free exchange of information and technology transfer, accelerating the development process of protein-based solutions for therapeutic, industrial, and environmental applications. Academia receives access to resources, new technology, and actual data via collaboration, while industry partners receive access to new scientific knowledge and advanced research.
• Collaborations play a pivotal role in protein engineering, where interdisciplinarity is being leveraged in addressing complex challenges such as protein stability, efficiency, and scalability. Through collaborations with industry practitioners, academicians can put novel protein designs to the test under actual application. Such practitioners can provide expert recommendations on issues that relate to scaled-up manufacturing and marketability. They also generate skilled human resources with talent that is capable of hastening protein engineering technology by establishing training modules in terms of a specific field. Regarding these, increased industry-academia interaction encourages innovation, increases protein engineering usefulness, and generates industry advancement in manufacturing, biotech, and pharmaceutical industries.

Market Restraining Factors

Complexity in Protein Design and Engineering Processes

• The complexity of protein engineering and design procedures is a serious issue in the market for protein engineering. Design and modification of proteins with a specific function require an elaborate understanding of their molecular structure, folding, and interaction. It involves a large number of advanced methodologies such as directed evolution, rational design, and computer modelling, each of which demands superior skills and infrastructure. Proteins are intricate macromolecules with numerous variables including amino acid sequences, molecular conformations, and environmental factors that influence their behaviour. It is a very challenging task to obtain the desired function, stability, and specificity with minimum possible side effects.
• There is also a new level of refinement from the requirements for tight regulation of protein production and folding. Protein therapy and industrial production are made difficult by misfolded proteins, that can cause things like decreased efficacy or unforeseen toxicity. Besides, there typically are cost, yield, and homogeneity issues in scaling proteins developed in a laboratory for industry. Overcoming the complexity of their engineering and design is one of the greatest challenges facing scientists and firms in their bid to provide efficient and functional solutions as demand for modified proteins in the medical and industrial markets increases.

Segmentation Analysis

The market scope is segmented because of by Product, by Application, by Protein Type, by End-use.

• By Product

Based on the Product of the market is segmented into Instruments, Reagents, Software & Services.

Reagents, Software & Services, and Instruments were the three product categories that dominated the majority of the protein engineering market. Instruments are significant in protein engineering activities because they are needed for activities like purification, characterisation, sequencing, and analysis of protein structures. These instruments are advanced equipment like mass spectrometers, high-performance liquid chromatography (HPLC) equipment, and X-ray crystallography equipment. These enable protein analysis to be precise and on a large scale, fundamental to science as well as trade. They have provided the backbone to the industry because they have supported protein engineering in the earliest phases of structure elucidation through that of functional optimization.

The dominance of the instruments segment is also due to the high cost of the devices and constant technological advancements. As new techniques such as cryo-electron microscopy and single-molecule spectroscopy emerge, market demand for advanced instruments grows, solidifying their market share. Instruments also have uses in a wide variety of industries including pharmaceuticals, biotechnology, and academic research, and therefore are a diversified and sought-after segment.

• By Application

Based on the Application of the market is segmented into Rational Protein Design, Directed Evolution, Hybrid Approach, De Novo Protein Design, Others.

Among the segments of application in the protein engineering market, Directed Evolution, Rational Protein Design, Hybrid Approach, De Novo Protein Design, and Others Direct Evolution has been dominating the market. The cause of its domination is its established success, adaptability, and widespread application across industries, primarily biopharmaceuticals and industrial enzymes. Directed evolution mimics the process of natural selection to engineer proteins with specified properties by inducing mutations and selecting variants that are better. This repetitive and adaptive process is less reliant on an exhaustive detailed understanding of protein function and structure than rational design, therefore providing a simpler and more viable alternative for most scientists.

The success of the technique lies in the fact that it plays a central role in the production of highly specific and active therapeutic proteins, including monoclonal antibodies and enzymes applied in treating metabolic disorders. In addition, directed evolution has transformed the industrial enzyme market to produce more resistant enzymes in industries like detergents, biofuels, and food processing. Its applicability in solving protein stability, efficiency, and activity challenges has positioned it as the preferred technique by most industries.

Key Findings:

• On May 21, 2024, 20/15 Visioneers, a top advanced science and technology management consulting and marketing services firm, and Quine Biologics Inc., and StableBody Technologies LLC, experts in Structure-based de-novo antibody design and pioneers in Rational Protein Design, is delighted to announce the partnership and collaboration to develop Next Generation Rational Protein Design for the North American and European markets.

Regional Snapshots

By region, Insights into the markets in North America, Europe, Asia-Pacific, Latin America and MEA are provided by the study. North America has led the protein engineering market historically through its strong pharmaceutical and biotechnology sectors, strong research facilities, and high level of investment in life sciences. North America has dominant biopharmaceutical leaders, academic organizations, and research institutes that continue to advance the field of protein engineering. The United States is the world's leader in advancing biopharmaceuticals such as monoclonal antibodies, enzymes, and protein therapeutics. Liberal financial support from public agencies, venture capitalists, and private industries supplements innovative research and commercialization of protein engineering technology further. On top of this, North America's established regulatory environment, strong emphasis on biopharmaceutical manufacturing and personalized medicine, and a favourable support system have favoured the growth of the market.

On the other hand, Asia-Pacific will be the fastest-growing market for protein engineering. The growth is fuelled by increasing investment in pharmaceutical and biotechnology research, expanding healthcare requirements, and the creation of manufacturing capability. China, India, and South Korea are some of the nation’s emerging as key players with their growing biotechnology sectors and low-cost production facilities. In addition, Asia-Pacific is aided by a huge patient base, growing use of sophisticated therapeutic solutions, and government support to foster research and development in life sciences. The presence of qualified professionals and growing emphasis on biopharmaceutical exports also support the growth potential of the region. All these combined make Asia-Pacific a prime driver of the global protein engineering market's future growth.

List of Companies Profiled

• Agilent Technologies
• Bruker Cor.
• Thermo Fisher Scientific, Inc.
• PerkinElmer, Inc.
• Waters Corp.
• Bio-Rad Laboratories
• Merck KGaA
• Danaher Corp.
• Genscript Biotech Corp.
• Amgen, Inc.n

Key Industry Developments

• Agilent Technologies Inc. launched a novel automated parallel capillary electrophoresis technology for protein analysis in January 2024.
• With the launch of its new proteomics CRO facility in Massachusetts in January 2024, Biognosys expanded its presence in the United States. With this, Biognosys would be in a position to provide its proteomics services to its biopharma customers in the United States. Bruker Corporation acquired Biognosys in January 2023.
• To distribute, market, and sell its line of FDA-cleared automated instruments, IFA products, and software in the United States, Thermo Fisher Scientific, Inc. revealed in December 2023 that it has entered into a distribution agreement with AESKU.GROUP GmbH.

Report Coverage

The report will cover the qualitative and quantitative data on the Global Protein Engineering Market. The qualitative data includes latest trends, market players analysis, market drivers, market opportunity, and many others. Also, the report quantitative data includes market size for every region, country, and segments according to your requirements. We can also provide customize report in every industry vertical.

Report Scope and Segmentations

Global Protein Engineering Market Regional Analysis

North America accounted for the highest xx% market share in terms of revenue in the Protein Engineering market and is expected to expand at a CAGR of xx% during the forecast period. This growth can be attributed to the growing adoption of Protein Engineering. The market in APAC is expected to witness significant growth and is expected to register a CAGR of xx% over upcoming years, because of the presence of key Protein Engineering companies in economies such as Japan and China.

The objective of the report is to present comprehensive analysis of Global Protein Engineering Market including all the stakeholders of the industry. The past and current status of the industry with forecasted market size and trends are presented in the report with the analysis of complicated data in simple language.

Protein Engineering Market Report is also available for below Regions and Country Please Ask for that

North America

• U.S.
• Canada

Europe

• Switzerland
• Belgium
• Germany
• France
• U.K.
• Italy
• Spain
• Sweden
• Netherland
• Turkey
• Rest of Europe

Asia-Pacific

• India
• Australia
• Philippines
• Singapore
• South Korea
• Japan
• China
• Malaysia
• Thailand
• Indonesia
• Rest Of APAC

Latin America

• Mexico
• Argentina
• Peru
• Colombia
• Brazil
• Rest of South America

Middle East and Africa

• Saudi Arabia
• UAE
• Egypt
• South Africa
• Rest Of MEA

Points Covered in the Report

• The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.
• The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. This report analysed 12 years data history and forecast.
• The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail.
• Data and information by market player, by region, by type, by application and etc., and custom research can be added according to specific requirements.
• The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

Key Reasons to Purchase

• To gain insightful analyses of the Protein Engineering market and have comprehensive understanding of the global market and its commercial landscape.
• Assess the production processes, major issues, and solutions to mitigate the development risk.
• To understand the most affecting driving and restraining forces in the market and its impact in the global market.
• Learn about the Protein Engineering market strategies that are being adopted by leading respective organizations.
• To understand the future outlook and prospects for the Protein Engineering market. Besides the standard structure reports, we also provide custom research according to specific requirements.

Research Scope of Protein Engineering Market

• Historic year: 2019-2022
• Base year: 2023
• Forecast: 2024 to 2032
• Representation of Market revenue in USD Million

Protein Engineering Market Trends: Market key trends which include Increased Competition and Continuous Innovations Trends: